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Fig. 10. Proposed mechanism by which RACK-I anchors activated PKC-ß on melanosome membranes. In human melanocytes, when PKC is activated by TPA treatment, or a physiologic signal, activated PKC-ß (PKC-ß*), but not activated PKC-{alpha} (PKC-{alpha}*), binds RACK-I and translocates to the melanosome membrane. Activated PKC-ß, anchored on the melanosome via RACK-I, then phosphorylates inactive tyrosinase (TYRi) at serine residues of amino acid positions at 505 and 509 of its cytoplasmic domain and activates tyrosinase (TYRa), leading to melanogenesis.





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