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Fig. 7. GEF activity of PLC- ${gamma}$ 1 for dynamin-1 upregulates dynamin-dependent SRE-dependent transcriptional activity. The SRE-luciferase reporter gene was transfected in PC12 cells which were stably transfected with indicated PLC- ${gamma}$ 1 mutant genes (vector, closed squares; PLC- ${gamma}$ 1^WT, open squares; PLC- ${gamma}$ 1^SH3, open triangles; PLC- ${gamma}$ 1^P842L, closed triangles). EGF-induced increase of luciferase activity was quantified as mean ± s.d.

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