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Fig. 3. Lithium dramatically slows the progression of cytokinesis and this effect is reversible by myo-inositol. Graphs of crane fly spermatocyte cell diameter measured at the cleavage furrow plotted on a logarithmic scale as a function of time for single cells treated with Li+. (A) The effects of 100% Li+ (added at the left arrow) and reversal with Ringer's solution (right arrow). The line on the left is the computer-generated best linear fit to the points between 2 and 4 minutes (i.e. expected curve in the absence of Li+). The dashed line on the right is the computer-generated best linear fit to the included points. (B) The effects of 25% Li+ Ringer's (added at the left arrow) and reversal with myo-inositol added to the Li+ Ringer's (right arrow) for the series of points indicated by +; the dashed line is the best linear fit to the points after addition of myo-inositol. The circles and the other best-fit line are from a control cell. (C) A control cell maintained in Ringer's solution. The line is the best linear fit to the circled points. (D) A cell treated with Li+, then with myo-inositol in Li+, at the times indicated on the graph. Cleavage slowed a few minutes after adding Li+ and sped up after myo-inositol was added. The line is the computer-generated best fit to the points after addition of myo-inositol.
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