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Fig. 5. Integrin ${alpha}$ 3ß1-deficient cells fail to polarize and migrate in a persistent and directional fashion. MK^+/+ cells, MK^–/– cells or MK ${alpha}$ 3 cells were plated sparsely onto LN-5 ECM and observed for 2 hours by time-lapse video microscopy. Intervals are indicated in minutes above each column. Arrows mark the position of a short-lived protrusion from an MK^–/– cell.

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