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First published online August 17, 2004

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Metalloproteinases - the matrix remodelled

Matrix metalloproteinases (MMPs) facilitate tissue remodelling by degrading components of the extracellular matrix (ECM). They can also release growth factors and bioactive ECM fragments in this way, as well as process cell surface molecules such as growth factor receptors and adhesion molecules. In Cell Science at a Glance (see p. 4016 + poster), Meng-Huee Lee and Gillian Murphy survey the >20 different members of the MMP family, providing their domain structures and information about their localization, regulation and functions.

Related articles in JCS:

Matrix metalloproteinases at a glance

Meng-Huee Lee and Gillian Murphy
JCS 2004 117: 4015-4016. [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content