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Fig. 9. A model for ${alpha}$ 3ß1-mediated keratinocyte survival at the cutaneous wound edge. (A) In quiescent epidermis, ${alpha}$ 6ß4 (black integrin) is polarized to the basal cell surface in hemidesmosomes, where it mediates stable adhesion of keratinocytes to LN-5 in the basement membrane. ${alpha}$ 6ß4 also contributes to maintenance of keratinocyte survival, along with other ECM receptors (see text for discussion); ${alpha}$ 3ß1 may contribute to survival, as well. (B) During epidermal wound healing, activated keratinocytes at the wound edge disassemble hemidesmomes, and ${alpha}$ 3ß1 (grey integrin) redistributes to the basal surface where it binds to newly deposited LN-5. In addition to promoting cell migration (Nguyen et al., 2000), ${alpha}$ 3ß1-LN-5 interactions at the wound edge may contribute to keratinocyte survival following the loss of ${alpha}$ 6ß4-mediated adhesion.

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