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Fig. 4. Calcium leak from the intracellular stores induced by puromycin occurs independently of IP3 and RyR stores. (A) Time course of a typical experiment of the passive Ca2+ leak induced by puromycin in digitonin-permeabilized LNCaP cells treated with ryanodine and heparin. At the end of experiment, ionomycin was added to indicate the size of the total releasable pool. (B) Sequential application of puromycin and IP3/cADPr to indicate the size of each releasable pool. At the end of experiment, ionomycin was also added to indicate the size of the total releasable internal calcium store. (C) Cumulative data (mean±s.e.m.) for the percentage of calcium released from internal stores.





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