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Fig. 1. Confocal images of 3-month-old wild-type mouse and human retinas. These images are high power insets of the OLM. (A) Crb1 is confined to the SAR, whereas ß-catenin localized more basally at the AJ. (B) Crb1 localized at the basal part of the F-actin localization in the PRC inner segments. (C) Mpp4, (D) Pals1, (E) Mupp1 and (F) Patj localized at the SAR, compared to the location of ß-catenin at the AJ. (G) aPKC co-localized with Crb1 to the SAR. (H-I) Crb2 and Crb3 localized to the SAR. A similar staining was detected in Crb1^-/- retina. (J) CD44 localized in the MGC apical villi, but did not co-localize with Crb1 in the SAR. Par6, moesin or ZO-3 were not detected in the OLM (data not shown). Claudin-1 to -5 and occludin were not detected in the retina, but claudin-2 and occludin were detected in the retinal pigment epithelium (RPE). (K) CRB1 localized at the SAR of the human retina, apical to ß-catenin in the AJ. (L) MUPP1 localized at the SAR of the human retina. (M) Schematic diagram of the localization for the different proteins at the SAR or AJ. Scale bar: 2.5 µm.

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