QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

	Help viewing high resolution images
	Return to article

(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.

Fig. 1. Signaling pathways for cell growth. Cell growth is stimulated by insulin or insulin-like growth factors (IGF) binding to their receptors (IRS). The activated receptor recruits phosphatidylinositol 3-OH kinase [PI(3)K] to the membrane, which then phosphorylates PtdIns(4,5)P₂, converting it to PtdIns(3,4,5)P₃. Increased levels of PtdIns(3,4,5)P₃ induce the activation of phosphoinositide-dependent protein kinase 1 (PDK1), which then stimulates 40S ribosomal protein S6 kinase (S6K). S6K mediates the phosphorylation of 40S ribosomal protein S6, which is thought to potentiate the recruitment of ribosomal-protein mRNAs from stores of messenger ribonucleoproteins (mRNps) to actively translating polysomes.

Return to article