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Fig. 6. Restriction point in HeLa cells. (A) Cell mass versus time for exponential growth (upper panel) or growth rate depending on birth size (lower panel). Shaded areas indicate 12-hour non-growing periods. The dotted horizontal lines mark the critical sizes for each growth rate. At the time of stopping cell growth, Cell 1 (green line, age 7 hours) has passed the restriction point (the critical size) but Cell 2 (red line, age 5 hours) has not. Arrows, labeled with M1, M1' etc., indicate the time of cell division. (B-D) Intermitotic time as a function of cell age for the first two mitoses and their summation. Shaded areas indicate cell age below 6 hours. Filled circles are the original data taken from Fig. 9 of Zetterberg and Larsson (Zetterberg and Larsson, 1995). Other open symbols are simulation for different growth rates: exponential growth (
); constant growth rate (
); and growth rate depending on birth size (
). The solid lines in C are the linear fits of the data points beyond cell age 6 hours including (green line) and excluding (red line) the two points highlighted by dashed red circles. Filled circles in D are the summation of the averaged intermitotic time of M1 and M2 for each cell age excluding the four points highlighted in (B) and (C). The colored lines are the linear fits of the data points before (cyan) and after (red) cell age of 6 hours.
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