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Fig. 1. Morphology and proliferation and differentiation potential of pATSCs. Culture expanded non-human primate ATSCs show the spindle-shaped fibroblastic morphology (A for low density and B for high density). Compared with pATSCs, pBMSCs are more heterogeneous and they have fibroblastic morphology (C). A single cell can be expanded into a clonal population and can generate colony forming units (CFUs) that are shown by Giemsa staining (D). Passage 3-4 pATSCs retain multilineage differentiation capability undergoing adipogenesis (E), osteogenesis (F) and chondrogenesis (G) in vitro. Cumulative population doublings with respect to passage number in multiple animal samples were measured (H). Bars, 40 µm (A); 30 µm (B).





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