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Fig. 7. Simulation of the effect of a massive, global increase of gIns(4,5)P2 in the ascidian egg. The temporal pattern of the Ca2+ spike much resembles that observed at fertilization. Simulation has been performed as in Fig. 4 with IgPtdIns(4,5)P2=25 µM second-1 in the whole system during the flash time (0.3 seconds). The black, red and blue traces represent the average level of cytosolic Ca2+, gPtdIns(4,5)P2 and luminal Ca2+, respectively.





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