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Fig. 7. Malformation of the jaws as a result of p120 depletion. Dissected craniofacial cartilage structures stained with Alcian Blue. The inset in (a) shows a schematic of the different craniofacial cartilage structures, including Meckel's cartilage (MC), ceratohyal (CH) and ceratobranchial cartilage (CB). All these structures are still present upon p120 knockdown (b) but are smaller compared with control MO-injected embryos (a). Boxed regions are enlarged in c-f. Higher magnification shows that the ceratohyal cartilage is less dense and delineated in embryos injected with p120 MO (d, see arrow and dotted line) compared with the same area in embryos injected with control MO (c). The same is true for the ceratobranchial cartilage (e,f), where the two arrows point out a ridge that is clearly less dense and composed of fewer cells in p120 MO-injected embryos.





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