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Fig. 10. Possible interaction of Drp1 (red) and dynein-dynactin complexes (green) with microtubules and mitochondria. Efficient fission of mitochondria (Control) facilitate transport of these organelles by anterograde motors including kinesin (yellow). Disruption of dynein-dynactin (p50) leads to the loss of Drp1 from mitochondria, which become more interconnected and consequently a poorer substrate for anterograde transport.





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