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Fig. 4. APP-interacting proteins Jip1b and X11{alpha} have different effects on nuclear AICD localization. (A) Extranuclear localization of Jip1b. Binding of AICD to Jip1b was associated with decreased nuclear levels of AICD. (B) Co-expression of Tip60 relocalized Jip1b into nuclear speckles. (C) Additional co-expression of AICD resulted in the formation of nuclear AICD-Jip1-Tip60 (AJT) complexes with a distinct speckle-like morphology, as compared with the smaller spherical spots generated by AFT-complexes. (D) Exclusive extranuclear localization of X11{alpha}. Binding of AICD to X11{alpha} was associated with decreased nuclear levels of AICD. (E) Co-expression of Tip60 had no effect on the extranuclear localization of either X11{alpha} or AICD. Bar, 10 µm.





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