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Fig. 6. Pharmacological inhibition of 
-secretase processing of APP blocks the formation of nuclear AFT-complexes. (A,B) The -secretase inhibitors DAPT and L-685,458 prevented the localization of APP-derived AICD into nuclear AFT-complexes. In cells with lower APP expression Fe65 was targeted to nuclear spots, whereas in cells with high levels of APP, Fe65 was retained at extranuclear localizations of APP including the ER/Golgi and vesicular structures. (C) Control experiment in the absence of -secretase inhibitors confirmed the formation of APP-derived nuclear AFT-complexes. Bar, 10 µm.
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