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Fig. 7. Formation of APP-derived nuclear AFT- and AJT-complexes in differentiated human neuroblastoma cells. (A) Nuclear and cytoplasmic localization of Fe65 expressed in SH-SY5Y cells differentiated with retinoic acid and BDNF. (B) Co-expression of Tip60, Fe65 and AICD led to the formation of nuclear AFT-complexes with spherical spot morphology. (C) Co-expression of Tip60, Jip1b and AICD led to the formation of nuclear AJT-complexes with speckle-like morphology. (D) AICD derived from full-length APP is targeted to nuclear AFT-complexes with spherical spot morphology. The inset shows a higher magnification of the soma, with a lower exposure to visualize nuclear spots, which are over-exposed in the overview. Bar in A: 20 µm for A,D; 10 µm for B,C,D inset.





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