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Fig. 9. Transmembrane-anchored Ykt6 constructs cannot localize normally to punctate Ykt6 structures. The C-terminal lipidation motif (CCAIM) of rat Ykt6 was replaced with the true transmembrane domain (TM) of Sec22b, VAMP7 or GOS-28. The chimeric proteins were expressed in PC12 cells and their subcellular localizations were examined by fluorescence microscopy using anti-Myc antibody and the indicated co-stained marker. Arrows point to gigantic aberrant membrane structures with acidic lumens induced by Ykt6 containing a VAMP7 transmembrane domain. Scale bar, 10 µm.





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