QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

Help viewing high resolution images Return to article

Fig. 4. Myosin Va and Myosin VIIa have no additive impact on visual function. Response amplitudes ± standard error plotted as a function of light intensity, from mice from the intercross between the Myo5a and Myo7a mutants (a presumptive null allele of myosin VIIa, Myo7a^4626SB, was used and is referred to as –): (A) a-waves; (B) b-waves. Four groups of mice are shown: the control group of mice that were heterozygous or wild type at both loci (Myo5a^{+/+,d or d-l}, Myo7a^+/?; all had normal pigmentation); mice homozygous for the Myo7a mutation and carrying a non-lethal genotype for Myo5a (Myo5^{+ or d/+,d or d-l}, Myo7a^–/–); mice homozygous for dilute lethal and heterozygous or wild type at the Myo7a locus (Myo5a^d-l/d-l, Myo7a^+/?); and mice homozygous for both dilute lethal and Myo7a mutations (Myo5a^d-l/Myo5a^d-l, Myo7a^–/–). There is no evidence of additivity of the of the 50% reduction in amplitude in dilute lethals and the 20% reduction with Myo7a mutants. Number of mice analyzed for each genotype: Myo5a^{+/+,d or d-l}, Myo7a^+/?, 9; Myo5^{+ or d/+,d or d-l}, Myo7^/–/–, 8; Myo5a^d-l/d-l, Myo7a^+/?, 13; Myo5a^d-l/d-l, Myo7a^–/–, 7.

Return to article