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Fig. 2. A model for neural intermediate filament transport. Neural IF proteins in the form of nonfilamentous particles, squiggles and longer IF (green) move rapidly along microtubles (blue) in association with kinesin (yellow) and cytoplasmic dynein and dynactin (orange). These motors are responsible for the timely delivery of neural IF particles and squiggles, the precursors to the long IF, to all regions of the neuron including the growth cone (on the right side of cell). Long neural IFs also move along neurites, albeit more slowly than the precursors. Their slower motility might be due to associations with IF-associated proteins such as plectin and bullous pemphigoid antigen (BPAG) (red). In addition, a population of neural IF proteins may move along actin structures (purple) in association with myosin Va (pink) in the cortical and peripheral domains of the growth cone.





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