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Fig. 2. NADPH oxidase localization in neutrophils. Diagram based on published information (Borregaard and Cowland, 1997). Approximately 10% of the oxidase is located at the plasma membrane and 90% is located in two separate compartments: the secretory vesicles and specific granules. Secretory vesicles contain several proteins [including complement receptor (CR-1), integrin ß2, N-formyl-methionylleucyl-phenylalanine receptor (fMLP-R)] and are rapidly translocated to the plasma membrane upon regulated exocitosis. Another fraction of gp91phox is included in specific granules, which can either fuse with the phagosome or eventually with the plasma membrane.





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