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Fig. 1. PIKE-binding proteins. Protein 4.1N binds to the extreme N-terminal 23 amino acids of PIKE through its C-terminal domain. Both subunits (p85 and p110) of PI 3-kinase directly interact with PIKE. Interestingly, the p85 subunit and protein 4.1N bind to the same region of PIKE. However, the structural requirements for PIKE binding to p110 differ somewhat from binding to p85, the N-terminal fragment from amino acids 24-262 being critical for p110 to bind to PIKE. In addition, the mGluR1- and mGluR5-associated protein Homer 1 binds to the proline-rich domain of PIKE (amino acids 187-190).





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