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Fig. 3. PIKE-L association with glutamate receptors. Homer dimers couple Ins(1,4,5)P3 receptor to mGluR1,5, and mediate intracellular Ca2+ signaling. Shank/Homer interactions link mGluR1,5 to NMDA receptors through PSD-95 and GKAP. PIKE-L/Homer interactions might link mGluR1,5 to the AMPA receptor GluR1 through the association of the N-terminus of PIKE and the C-terminal domain of 4.1N. This postsynaptic complex might regulate the communication between AMPA receptors and mGluRs.





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