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Fig. 6. Accumulation of p190RhoGAP. PDBu treatment induces the rapid translocation of p190RhoGAP from actin stress fibres (A-C) to the sites of podosome formation (D-F). Note the almost complete displacement of p190RhoGAP following PDBu stimulation (E), despite the presence of prominent actin stress fibres in the centre of the cell (D,F). The localisation of p190RhoGAP with membrane ruffles remains unchanged (arrows). Scale bar: 20 µm.





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