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Fig. 8. SB202190 and olomoucine exert differential effects on NF transport in NB2a/d1 cells. (A-C) Sequential images of axonal neurites of GFP-M-transfected cells captured at the indicated intervals (in minutes) before and after addition of SB202190 (A) or olomoucine (B,C). The time of addition is indicated by the arrow in each case. (C) Images of cells 5-15 minutes after addition of olomoucine and mitotracker. Axonal neurites were imaged under fluorescent optics to visualize GFP and rhodamine optics to visualize mitotracker (Mito). False-color and merged images were prepared as described in the legend for Fig. 7 and in Materials and Methods. Note that SB202190 did not impair the transport of GFP-tagged structures (A). Note also that olomoucine inhibited transport of GFP-tagged structures, but did not inhibit transport of mitotracker-labeled structures in the same neurites (B,C).





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