spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online September 29, 2004

Journal of Cell Science 117, 2104e (2004)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Nuclear Velcro


The nuclear envelope of eukaryotic cells is part of the endoplasmic reticulum (ER), a membrane system that intersects with several organelles. The best understood of these intersections is the budding yeast nucleus-vacuole (NV) junction. On p. 4959, Erik Kvam and David Goldfarb report that the yeast oxysterol-binding protein (OSBP) homolog Osh1p is targeted to NV junctions through a direct physical interaction with the Nvj1p protein on the nuclear envelope. During nutrient starvation, Nvj1p forms Velcro-like patches with Vac8p on vacuole membranes, through which nuclear fragments are pinched off for degradation in the vacuole - this process is called piecemeal microautophagy of the nucleus (PMN). Kvam and Goldfarb use a GFP-Osh1p fusion to show that recruitment of Osh1p to NV junctions and PMN structures is proportional to cellular Nvj1p levels. Although OSH1 is not needed for NV junction formation or PMN, yeast lacking the entire seven-member OSBP family exhibit defective PMN. This leads the authors to suggest that an activity shared by the OSBPs is involved in modification or transport of lipids that are required for PMN.


Related articles in JCS:

Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p in Saccharomyces cerevisiae
Erik Kvam and David S. Goldfarb
JCS 2004 117: 4959-4968. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content