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Fig. 1. Conceptual framework for the quantitation of subnuclear organization by intranuclear informatics. Four main groups of parameters, selected on the basis of inherent biological variability, are examined. Parameters that describe domain quantity and nuclear size comprise group 1 (upper left panel). Group 1 includes: number of domains and domain density. Parameters that describe domain size and variability comprise group 2 (upper right panel). Group 2 includes: domain size mean, median, standard deviation, variance, skewness, kurtosis, coefficient of variation, and index of dispersion. Parameters that describe the domain spatial randomness, which is based on domain nearest-neighbor distances, comprise group 3 (lower left panel). Group 3 includes: domain nearest-neighbor mean, median, standard deviation, variance, skewness, kurtosis, coefficient of variation, index of dispersion, domain density, nearest-neighbor distance mean and variance expected for a random distribution, ratios between actual and expected mean and variance, and the standard error in the nearest-neighbor distances. Parameters that characterize the radial position of domains comprise group 4 (lower right panel). Group 4 includes: mean perimeter radius, mean domain radius, and mean relative domain radius.

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