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Fig. 4. TEM of nuclear lamina defects in klp61F ncd mutants. Somatic cells in larval brains of wild-type (A) and klp61F4 ncd1/klp61F3 ncd1 mutant (B-D) animals with nuclear lamina indicated with red arrows, condensed chromatin indicated by blue arrows and mitochondria indicated by green arrows. (A) Nuclear lamina in a wild-type cell lies between condensed chromatin and cytoplasmic mitochondria, shown in the insert at 2x magnification. (B) Somatic cell in klp61F4 ncd1/klp61F3 ncd1 larval brain lacks detectable nuclear lamina lying between mitochondrion and condensed chromatin. A region between a mitochondrion and chromatin is shown in the inset at 2x magnification. (C) Nuclear lamina surrounding separate masses of condensed chromatin. (D) Region lying between marked lamina is shown at 3x magnification. Fenestration of the nuclear lamina in prometaphase or metaphase cells was inferred from uniform staining throughout mitotic cells whereas interphase cells showed lighter staining of nucleoplasm in comparison to darker staining of the cytoplasm and by position of condensed chromatin near the cell center rather than the nuclear periphery. Interphase cells were more than tenfold more frequent than cells in mitosis. Bars, 2 µm.





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