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Fig. 8. Endogenous Cdc25B partly translocates to the cytoplasm after exposure to UV-C. One hour before 50 J/m2 UV-C treatment, HeLa cells were incubated with the p38 inhibitor SB202190 (SB), leptomycin B (LMB) or the MEK1 inhibitor PD98059 (MEK) as indicated in images on the left. Cells were fixed 1 hour after UV-C exposure. Representative images of the B1:5 and cyclin B1 immunostaining are shown. Cells that express high levels of cyclin B1 (G2 cells) are indicated with the letter a in the images showing Cdc25B staining (B1:5). The cytoplasmic translocation of Cdc25B is observed in cells treated with UV-C and with UV-C in combination with the MEK1 inhibitor but not in untreated cells, or cells treated with UV-C in combination with leptomycin B or the p38 inhibitor.





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