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Fig. 6. Rad18^Sc protein localizes to unsynapsed axial loops. (A) The breakpoints (arrows) in chromosomes 1 and 13 of the T(1;13)70H (T, left) and T(1;13)Wa (T', right) mice are illustrated. Meiotic bivalents in T/T' double heterozygote mice are shown in the middle. (B) Immunostaining of Sycp3 (red) and Rad18^Sc (green) of T(1;13)70H/T(1;13)Wa double-heterozygous spermatocytes. Rad18^Sc protein localizes to the XY body and also to the translocation bivalent that shows incomplete synapsis. The unsynapsed axial loop of the 1¹³ bivalent is often found close to the XY body. The arrow indicates the X and Y bivalent (XY body) and the arrowhead points to the 1¹³ translocation bivalent. Bar, 20 µm.

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