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Fig. 2. Sequence comparisons of SmAV with human supervillin and archvillin. (A, top) The SmAV sequence. The muscle-specific sequence (insert 1) is in yellow (Oh et al., 2003) and the nuclear targeting sequences is in blue. The CaP-binding domain is represented by the red box. (A, bottom) The alignment of N-terminal amino acid sequences of ferret SmAV with those of human supervillin and human archvillin. Identical residues are in black; the second muscle-specific insert in skeletal-muscle archvillin is in green. The three sequences in skeletal-muscle but not smooth-muscle archvillin are boxed and numbered. Residue numbers are given on the right. The SmAV sequence data are available from GenBank (accession number AY380816). (B) Domain analysis of SmAV, based on homology with domains in supervillin (Chen et al., 2003) and motif searching programs (http://scansite.mit.edu/, http://www.ncbi.nlm.nih.gov/). Domains are marked with residue numbers. Sequences corresponding to the predicted binding sites for myosin II (lavender) and F-actin (brown) are shown. The CaP-binding domain is represented by the red box.

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