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Fig. 7. Basolateral-to-apical [125I]-RAP ratio over time in megalin (MEGt) and LDL receptor-related protein (LRPt) transfected MDCK cells and control MDCK cells. Although non-transfected MDCK cells had a basal, saturable apical-to-basolateral flux of [125I]-RAP, overexpression of the chimeric receptor containing the cytoplasmic tail of megalin significantly enhanced this flux, which remained saturable.





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