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Fig. 3. Deafness in Cld11-/- mice. (A) ABR to stimuli of 0-80 dB sound pressure level (16 kHz) in 10-week-old Cld11+/+ and Cld11-/- mice. (B) Hearing thresholds of 10-week-old Cld11+/+, Cld11+/- and Cld11-/- mice at various sound frequencies. Cld11+/+ and Cld11+/- mice show normal hearing thresholds (10-20 dB SPL), whereas Cld11-/- mice show abnormally increased hearing thresholds (40-60 dB SPL).





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