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Fig. 3. Cdc42 but not Rac1 governs actin rearrangements associated with Rickettsia conorii invasion. (A) Expression of dominant negative N17Cdc42, but not N17Rac1 in Vero cells inhibited R. conorii-mediated invasion when compared to non-transfected (Control) cells as assessed by a fluorescence-based invasion assay (see Materials and Methods). Expression of either construct had no effect on bacterial adherence (data not shown). (B,C) Extracellular R. conorii were found to colocalize with endogenous Cdc42 (arrows) in non-transfected cells within 15 minutes of bacterial infection. (D) Colocalization of Cdc42 with bacteria is not caused by antibody crossreactivity with bacteria (arrowhead). Bar, 4 µm.





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