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Fig. 8. Model of putative interactions involved in the uptake of Rickettsia conorii in non-phagocytic mammalian cells. Various signaling pathways can activate the Arp2/3 complex independently or in synergy. Internalization of R. conorii most likely involves the interaction of R. conorii surface protein(s) with an unidentified host cell receptor(s) (black rectangle with question mark), which serves to activate multiple pathways involving Cdc42, PI 3-kinase, Src, FAK and cortactin, ultimately leading to Arp2/3-dependent actin cytoskeletal changes that drive bacterial entry (see Discussion). Putative associations of proteins during bacterial entry are indicated by question marks and dotted arrows.





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