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First published online October 13, 2004

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Nuclear actin dons cap

Actin and actin-binding proteins (ABPs) have well-established functions in the cytoplasm as regulators of cytoskeletal architecture and cell motility. It is becoming increasingly clear that they also exist in the nucleus. But, since the nucleus seems to lack a filamentous actin network, their roles there have remained something of a mystery. Jan Gettemans and co-workers now show that a nuclear ABP still regulates motility but hint at a very different control mechanism (see p. 5283). They have examined the capacity of CapG – a nuclear and cytoplasmic actin-capping protein implicated in metastasis – to stimulate the invasive ability of epithelial cells. Surprisingly, they find that this depends on nuclear localization of CapG, which the authors show is actively mediated by the import receptor importin ß. They also show that the invasive effects of CapG depend on signalling through the Ras-PI3K pathway. Less predictable is their observation that CapG can regulate transactivation by the viral transcription factor VP16. Their findings thus indicate that control of cell motility by CapG does not depend on its cytoplasmic actin-capping activity but might instead involve transcriptional modulation.

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Increased importin-ß-dependent nuclear import of the actin modulating protein CapG promotes cell invasion

Veerle De Corte, Katrien Van Impe, Erik Bruyneel, Ciska Boucherie, Marc Mareel, Joël Vandekerckhove, and Jan Gettemans
JCS 2004 117: 5283-5292. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?