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Fig. 3. Potential therapeutic implications of the NF-{kappa}B-mediated blockade of TNF-{alpha}-induced JNK signaling. A positive-feedback loop between TNF-{alpha} and NF-{kappa}B drives chronic inflammatory states; several pharmacological agents can be used to treat these states. The effects of MKK7-mimicking peptides are also shown (Papa et al., 2004), which support the therapeutic feasibility of blocking the NF-{kappa}B anti-apoptotic activity without significantly affecting the immune system.





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