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Fig. 2. Abnormal epidermal morphology caused by loss or reduction of tsp-15 in C. elegans. (A-I) Nomarski images of N2 L4 larva (A,D), tsp-15(RNAi) L4 larva (B,E), bli-2(e768) adult (C,F), tsp-15(sv15) L3 (G) and L4 larva (H), and Ex[P_dpy-7::tsp-15His]; tsp-15(sv15) L4 larva (I) are shown. tsp-15(RNAi) animals (B,E) show numerous epidermal blisters and a swollen body morphology. Unlike bli-2(e768) mutants (C,F), unidentified material accumulates within the blisters in tsp-15(RNAi) animals (arrows in B and E). tsp-15(sv15) mutants typically have milder defects than tsp-15(RNAi) animals (compare G with B and E) and sometimes only exhibit a dumpy shape (H). (I) Rescue of sv15 by expression of the wild-type tsp-15 gene in the hypodermis. Bars, 50 µm.

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