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Fig. 1. Trichostatin A (TSA) increases platelet-derived growth factor ß-receptor (PDGFRB) promoter activity through the CCAAT motif and attenuates its repression by p73{alpha}. (A) The HindIII/SacI promoter construct containing the CCAAT motif without the GC box and the SacI/SacI constructs with a mutated or wild-type CCAAT motif were co-transfected into NIH3T3 cells with or without TSA treatment. Values represent mean luciferase activity and error bars indicate standard deviation of triplicate samples. (B) The SacI/SacI construct was co-transfected with p73{alpha} or vector alone (mock) and treated with or without TSA. (C) The SacI/SacI construct containing the mutated or wild-type CCAAT motif was co-transfected with CBP, p300, or vector alone.





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