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Fig. 2. Mitotic effects in C. elegans gonads of ubc-2 and mat-1/apc-3 mutant combinations. Distal gonads were stained with pHisH3 antibody after 40 hours at 25°C. Significant increase in pHisH3 staining is seen in the mutant combinations with ubc-2(RNAi) but not apc-11(RNAi) indicating an increase in the number of M-phase chromosomes. Therefore, ubc-2 and mat-1 interact genetically to affect progression through the cell cycle in this region of the gonad.





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