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Fig. 3. Phosphorylation-dependent interaction of GGA1 with BACE. Intensity images of GGA1 (A,C,E,G) and pseudocolored FLIM images when co-transfected with wild-type BACE (WT-BACE; D) or the BACE-S498D (F) and BACE-S498A (H) mutants in N2a cells. In the absence of an acceptor or Cy3-tagged, non-phosphorylated BACE mutants (S498A), no change in fluorescence lifetime was detected. WT-BACE and pseudo-phosphorylated BACE mutants (S498D) showed a significant decrease of fluorescence lifetime in the juxtanuclear compartment.





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