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Fig. 3. Kinetochore attachment error correction in mitosis. (A) Description of the most common kinetochore attachment errors, their ability to activate the checkpoint, and the consequences if they are not detected before anaphase onset. (B) Left: diagram of the composition of the chromosomal passenger complex as presently understood (subunits shown in contact have been shown to interact in vitro, and no effort has been made to show the stoichiometry of the various subunits within the complex). Right: model showing the predicted activity of aurora B at centromeres under different conditions of microtubule occupancy.





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