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Fig. 6. VP8 facilitates the passage of molecules through the intestinal epithelium in an animal model. (A) Experiments were performed either in rats that had previously received an intraperitoneal injection of streptozotocin (75 mg/kg of body weight) to induce them to become diabetic (closed squares) or a mock injection (closed triangles). (B) Rats with streptozotocin-induced diabetes received insulin (Humulin, intermediate action) parenterally (6 IU; continuous lines) or orally (30 IU; broken lines). (C) Rats with streptozotocin-induced diabetes orally received VP8 (100 µg) (broken lines) or VP8 (100 µg) and insulin (30 IU) (continuous lines). Blood samples were taken after overnight fasting (time=0) or at different times after the animals received their diet. Each line corresponds to the results obtained with one animal.
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