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Fig. 6. Mapping the sequence region of hnRNP C1 required for ROCK-induced cytosolic translocation. (A) Schematic presentation of various domains of hnRNP C1 and the constructs of its deletion mutants. HnRNP C1 contains a RNA binding domain (RBD: 1-104), a nuclear retention sequence (NRS: 88-165), and a C-terminal acidic region. (B) HEK293T cells on 35 mm dishes were co-transfected with 0.5 µg of expression plasmid of ROCK(CAT) or control vector together with 1 µg of pDsRed-hnRNP C1 or its deletion mutants as indicated. After expression for 20 hours, cells were fixed, stained with DAPI and observed by fluorescence microscopy for nuclei and DsRed detection.





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