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Fig. 3. Intact DBD domain in RXR ${alpha}$ is responsible for NES function. (A) Schematic representation of RXR ${alpha}$ and its mutants. (B) Subcellular localization of RXR ${alpha}$ mutants. RXR ${alpha}$ and its mutants were fused to GFP, then transfected into NIH3T3 cells. After transfection, cells were stained with Hoechst 33258 to visualize nuclei. Localizations of GFP-RXR ${alpha}$ protein and its mutants were visualized using fluorescent microscope. (C) Shuttling behavior of RXR ${alpha}$ and its different mutants. GFP-RXR ${alpha}$ and different GFP-RXR ${alpha}$ mutants were separately transfected into NIH3T3 cells as indicated, then fused with HeLa cells. The heterokaryons were visualized as described in Fig. 1A. Arrows indicate HeLa nuclei.

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