spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 5. Primitive endoderm specification of mouse ES cells can be induced solely by cellular aggregation regardless of the presence of external factors (LIF and BMP4), which are sufficient to maintain self-renewal of ES cells in monolayer culture (top). ES-cell aggregation induces repression of the Nanog gene in the outer layer independent of the LIF/STAT3 and BMP4/Smads pathways (Cavaleri and Schöler, 2003; Ying et al., 2003). The repression of Nanog subsequently leads to ES cells differentiating into the primitive endoderm (bottom).





Right arrow Return to article