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Fig. 10. Proposed model of TrkB.T1 action in the induction of filopodia. Interaction of TrkB.T1 with the p75^NTR, leads to the formation of filopodia (grey arrow). This effect can be blocked by either the MC192 antibody or the dominant negative p75 ${Delta}$ ICD (inhibitory agents in red). The dominant negative action of the TrkB.FL receptor can be explained by its competition with TrkB.T1 for binding to either p75^NTR (right margin) or by scavenging TrkB.T1 (left margin). NGF, BDNF, TrkB-IgG or K252a were without effect on this signalling mechanism. The short p75^NTR (in blue) indicates a possible (albeit weaker) such signalling via a p75^NTR lacking an intact extracellular domain (see p75^NTR knockout mice experiments)

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