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Fig. 6. TrkB.T1-induced formation of filopodia is dependent on p75NTR but can not be mimicked by application of NGF. Application of 8 µg/ml MC192 (a monoclonal antibody that binds to an extracellular epitope of p75NTR) to TrkB.T1-overexpressing neurons reduced the outgrowth of filopodia to control levels (**significantly different from TrkB.T1-GFP; P<0.01). Basal levels of filopodia remained unaffected (see GFP controls). Application of 100 ng/ml NGF to GFP transfected controls does not mimic the effect of TrkB.T1 expression (n>30cells; five experiments).





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