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Fig. 9. Reduction of TrkB.T1-induced filopodia formation in hippocampal neurons from p75 knockout mice. Neurons from wt or p75NTR knockout mice were transfected with either TrkB.T1-GFP or GFP. The reduction in the density of TrkB.T1-induced filopodia in p75NTR knockout compared with wild-type mice is highly significant (P<0.0005). Both TrkB.T1-transfected groups were also significantly different from the respective GFP-transfected negative controls (*P<0.0001). The number of filopodia in GFP-expressing cells from p75NTR knockout mice was not significantly different from GFP-expressing wild-type cultures (P>0.15) (n=28-52 cells from two to three independent experiments).





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