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Fig. 5. Retinas containing the GFP:Myo3A transgene have reduced numbers of rod photoreceptors compared with cones. (A) GFP:Myo3A retina with areas that have reduced numbers of rods (arrows) compared with other regions within the retina and to wild-type retina (B). The other retinal layers in the transgenic eye are unaffected by the transgene. (C) The GFP:Myo3A retina contains predominantly cone photoreceptors (C) that are characterized by lipid droplets in their inner segment and fewer rods. No rod inner segments and only a few rod outer segments (ROS) are observed in the transgenic retina unlike the greater number of intact rod inner and outer segments interspersed with cones found in a wild-type retina (D). N, nucleus. Scale bars: (A,B) 100 µm; (C,D) 1 µm.





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